THE Calgary Stampeders (4-12-1) and Saskatchewan Roughriders (9-7-1) will meet for a Week 21 game Saturday at Mosaic Stadium in Regina. Kickoff is scheduled for 7 p.m. ET (TSN/CFL+). Below we analyze BetMGM Sports Betting lines around the Stampeders vs. Roughriders oddsand make sure our expert CFL Picks and Predictions.

The Stampeders failed to qualify for the playoffs, so this will be the final game of their season. Calgary was crushed 42-20 in Hamilton last week, and the Stamps are 0-8-1 in a row (SU) while being 1-8 against the spread (ATS) over the 9 matches.

The losing streak includes a 37-29 Saskatchewan win at Calgary in Week 16, becoming a 3-point favorite as the Over (49) connected.

The Roughriders have won 4 games in a row, while covering in each of those games. Saskatchewan has also scored 28 or more points in 4 consecutive games.

Stampeders vs. Roughriders

Provided by BetMGM Sports Betting; access USA TODAY Center for Sports Scores and Sports Betting Odds for a complete list. Lines last updated at 11:11 a.m. ET.

• Money Line (ML): Stampeders +165 (bet $100 to win $165) | Roughriders -200 (bet $200 to win $100)
• Against the spread (ATS): Stampeders +3.5 (-105) | Roughriders -3.5 (-115)
• More/Less (Y/U): 49.5 (O: -105 | U: -115)

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Key injuries to the Stampeders and Roughriders

Stampeders

• Database Daniel Amoako (knee) out
• W.R. Erik Brooks (arm) out
• W.R. Ismaël Hyman (calf) outside
• QB Matt Shiltz (neck) outside
• W.R. Cole Tucker (hamstring) out
• kg Darius Williams (wrist) out

Roughriders

• R.B. Ryquell Armstead (shoulder) out
• kg Adam Auclair (knee) questionable
• W.R. Shawn Bane Jr. (knee) out
• D.L. Malik Carney (ankle) questionable
• OL Pierre Godber (ankle) out
• D.L. Korte-Moore Lake (knee) out
• kg Melique Straker (hip) out

Stampeders and Roughriders picks and predictions

Prediction

Roughriders 32, Stampeders 19

Money line

The Roughriders (-200) will cost you 2x your potential return, which is just a bit too expensive for a standalone bet. If you were to throw this into a multi-stage debate, that would mitigate the risk somewhat.

PASS.

Against the spread

SASKATCHEWAN -3.5 (-115) is worth checking out as they close out the regular season.

Calgary +3.5 (-105) is 0-8-1 ATS and 0-8-1 ATS in the last 9 games since August 4, including a 8-point loss to Saskatchewan on September 20.

On the other hand, the Roughriders have covered four in a row, using their high-powered offense to get the job done.

More/Less

MORE THAN 49.5 (-105) is the skinny one, but go for a half-unit game at most.

In this series, the Over has conceded in 3 of the last 4 meetings, while the Over has connected in the last 3 meetings at Mosaic Stadium.

The Stampeders have won the Over in 7 of the last 10 games, including the Week 16 meeting in Calgary.

For Saskatchewan, the Under and Over have alternated in each of the last 11 outings, so be careful.

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