Three-time world champion Israel Vazquez has died at the age of 46 from cancer, WBC President Mauricio Sulaiman announced on Tuesday. ESPN.

“Israel Vazquez finally rests in peace. May God give strength and support to his wife Laura, their children, their family and their friends in these difficult times…” Sulaiman posted on social media. “Thank you Israel for the many good memories you have left us through your actions inside the ring but especially outside. You are now eternal, rest in peace, everything will be fine.”

The WBC announced in November that Vazquez had been diagnosed with cancer and a GoFundMe was created to appeal for donations for his treatment.

Nicknamed “Magnifico,” Vazquez was known for his speed and punching power. He held the IBF, WBC and The Ring super bantamweight titles during his 49-fight career, compiling a record of 44-5 with 32 knockouts en route to becoming one of Mexico’s most famous boxers.

Vazquez had a historic rivalry with compatriot Rafael Marquez, during which they fought a four-fight series. They split the series 2-2, with Vazquez’s loss to Marquez in May 2010 serving as the final professional fight of his career.

Legendary boxing trainer Freddie Roach reacted to Vazquez’s death in a statement to Boxing scene: “Forever a world champion and a boxing legend. One of the best boxers I have ever had the privilege to work with, a world champion. Israel, my friend, may you rest in peace now . My condolences to the Vazquez family and all those who called Israel their friend.